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Area of Science:

  • Biomaterials Science
  • Oral Biology
  • Cell Biology

Background:

  • Strontium is an alkaline earth metal with known therapeutic applications, including osteoporosis treatment and dental applications.
  • Its effects on gingival fibroblasts, crucial for periodontal health and implant success, are not well understood.
  • Gingival fibroblasts play a key role in forming a soft-tissue barrier around oral implants.

Purpose of the Study:

  • To investigate the in vitro effects of strontium on human gingival fibroblast activity.
  • To assess strontium's potential to enhance gingival fibroblast attachment to healing abutments.
  • To explore strontium's role in preventing peri-implantitis by improving soft-tissue integration.

Main Methods:

  • In vitro studies using human gingival fibroblasts.
  • Treatment with strontium citrate at varying concentrations (0.5-1.0 mM).
  • Assessment of cell activity, apoptosis, and fibroblast attachment to healing abutments using scanning electron microscopy.

Main Results:

  • Strontium citrate significantly increased human gingival fibroblast activity.
  • Strontium supplementation reduced apoptosis in gingival fibroblasts.
  • Scanning electron microscopy confirmed increased gingival fibroblast attachment to healing abutment surfaces with strontium treatment.

Conclusions:

  • Strontium positively influences human gingival fibroblast behavior in vitro.
  • Strontium enhances the attachment of gingival fibroblasts to implant abutments.
  • These findings support further research into strontium for preventing peri-implantitis and maximizing soft-tissue barrier formation.