Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Sense of Self: Reflected Self-Appraisal and Social Comparison

The Sense of Self: Reflected Self-Appraisal and Social Comparison

According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...

Introduction to Special Senses

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...

Tactile and Chemical Senses

Tactile and Chemical Senses

Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.

Dynamic Equilibrium

Dynamic Equilibrium

A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...

Excitation-Contraction Coupling in Skeletal Muscles

Excitation-Contraction Coupling in Skeletal Muscles

Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action...

Gene Regulation in Microbial Communities: Quorum Sensing

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spectrotemporal signatures of driving and modulatory circuits across cortical and subcortical networks.

bioRxiv : the preprint server for biology·2026

Same author

Dose-dependent power and connectivity modulation of low frequency oscillations through transcranial magnetic stimulation in non-human primates.

bioRxiv : the preprint server for biology·2026

Same author

Vitamin D in Endocrine Disorders: A Broad Overview of Evidence in Musculoskeletal, Thyroid, Parathyroid, and Reproductive Disorders.

Pharmaceuticals (Basel, Switzerland)·2026

Same author

Optimizing electrode placement and information capacity for local field potentials in cortex.

NeuroImage·2026

Same author

Revisiting alpha-theta cross-frequency dynamics during working memory.

Cerebral cortex (New York, N.Y. : 1991)·2026

Same author

Is there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex?

Nature neuroscience·2025

Same journal

Structural proteomics reveals that misfolded nascent proteins expose buried lysines for ubiquitination and rapid proteasomal degradation.

Cell reports·2026

Same journal

Physical interactions within the SIR heterochromatin complex potentiate inter-subunit communication and gene repression.

Cell reports·2026

Same journal

An IGF2BP3-dependent metabolic circuit governs macrophage recruitment and immunosuppression in glioblastoma.

Cell reports·2026

Same journal

A cold-induced GDF15-secreting adipocyte subpopulation regulates energy homeostasis through endocrine signaling.

Cell reports·2026

Same journal

RelB drives integrin-mediated stress tolerance and relapse in high-grade serous ovarian cancer.

Cell reports·2026

Same journal

Yeast β-glucan supplementation supports immunometabolic anti-tumor responses and reverses obesity-induced dysfunction via trained hematopoiesis.

Cell reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 23, 2026

Visualization of Cortical Modules in Flattened Mammalian Cortices

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

Dynamic Modulation of Cortical Excitability during Visual Active Sensing.

Annamaria Barczak¹, Saskia Haegens², Deborah A Ross¹

¹Translational Neuroscience Division, Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.

|June 20, 2019

Summary

This summary is machine-generated.

Active viewing involves eye movements like saccades, influencing visual processing in the primary visual cortex (V1). This study reveals context-dependent modulation, impacting neuronal activity and visual perception during natural scene exploration.

Keywords:

CSD LFP V1 active sensing eye movements local field potential macaque neuronal oscillations saccadic modulation vision

More Related Videos

Corticospinal Excitability Modulation During Action Observation

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

Related Experiment Videos

Last Updated: Jan 23, 2026

Visualization of Cortical Modules in Flattened Mammalian Cortices

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

Corticospinal Excitability Modulation During Action Observation

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

Area of Science:

Neuroscience
Visual Neuroscience
Computational Neuroscience

Background:

Traditional visual physiology studies often use fixed gaze, limiting understanding of active viewing.
Active visual exploration involves systematic eye movements (fixations and saccades) for information acquisition.
Previous research indicates saccade-related signals and extra-classical receptive fields modulate visual processing during active viewing.

Purpose of the Study:

To investigate the influence of eye movement-related signals on visual processing in primary visual cortex (V1).
To isolate contextual modulatory effects by comparing visual responses with and without direct foveal input during active viewing tasks.
To elucidate the mechanisms underlying contextual modulation in V1 during naturalistic visual exploration.

Main Methods:

Utilized active viewing tasks in nonhuman primates to compare visual responses under different conditions.
Employed tasks that allowed for the isolation of contextual influences from direct foveal stimulation.
Applied time-frequency decomposition to analyze neuronal oscillatory activity and its phase reset.

Main Results:

Identified strong contextual modulation in V1, characterized by excitability and response amplification post-fixation onset.
Observed a transition to suppression of neural responses leading up to the next saccade.
Found that this amplification-suppression cycle is associated with a phase reset of ongoing neuronal oscillations.

Conclusions:

Eye movement-related contextual modulation significantly impacts stimulus processing in V1.
Active visual sensing, influenced by saccade-related signals, fundamentally differs from passive visual processing paradigms.
Neuronal oscillations and their phase resetting play a crucial role in mediating contextual modulation during active viewing.