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Updated: Jan 23, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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Statin Effects on Incidence, Treatment Success, and Mortality of Clostridium difficile Infections

Marian L Gaviola1, Emily C Scribe1, Haley N Leverett1

  • 1University of North Texas System College of Pharmacy, Fort Worth, TX, USA.

Journal of Pharmacy Practice
|June 21, 2019
PubMed

Insights

Statin use may reduce the risk of developing Clostridium difficile infection (CDI) and improve treatment outcomes. However, its impact on mortality remains uncertain, requiring further research.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Medicine

Background:

  • Clostridium difficile infection (CDI) is a significant healthcare-associated infection.
  • Statins are widely used lipid-lowering medications with potential immunomodulatory effects.

Purpose of the Study:

  • To review the impact of statin use on CDI incidence, treatment success, and mortality.
  • To assess the protective effects of statins in patients at risk for or diagnosed with CDI.

Main Methods:

  • A comprehensive literature search was conducted up to January 2019.
  • Included studies evaluated the effects of statins (HMG-CoA inhibitors) on CDI-related outcomes.
  • Eight retrospective studies were identified for review.

Main Results:

  • Five studies suggested statins may decrease the risk of developing CDI.
  • One study indicated improved treatment response against CDI with statin use.
  • Three studies examined statin use and CDI mortality, with only one finding a significant benefit.

Conclusions:

  • Statin use may offer protection against CDI development and enhance treatment success.
  • The benefit of statins on CDI-related mortality is currently unclear.
  • Larger, prospective studies are needed to confirm findings and identify optimal patient populations.
Abstract

Keywords:
Clostridium difficileHMG-CoA inhibitorsinfectious diarrheainfectious diseasestatins

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