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Detection of True IgE-expressing Mouse B Lineage Cells
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True First-Pass Effect.

Omid Nikoubashman1, Sven Dekeyzer1, Alexander Riabikin1

  • 1From the Department of Neuroradiology (O.N., S.D., A. Riabikin, A.K., A.M., M.W.), University Hospital RWTH Aachen, Germany.

Stroke
|June 21, 2019
PubMed
Summary
This summary is machine-generated.

Achieving complete reperfusion in stroke patients during the first pass of mechanical thrombectomy significantly improves clinical outcomes. This "first-pass effect" is crucial for better recovery after stroke interventions.

Keywords:
humansoutcome assessment (health care)reperfusionstrokethrombectomy

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Area of Science:

  • Neurology
  • Interventional Neurology
  • Stroke Medicine

Background:

  • Complete reperfusion (mTICI 3) after stroke thrombectomy is linked to favorable outcomes.
  • The specific benefit of achieving reperfusion in a single pass (first-pass effect) on clinical outcomes remains under-investigated.

Purpose of the Study:

  • To investigate if complete reperfusion achieved in a single thrombectomy pass is associated with improved clinical outcomes compared to multiple passes.
  • To determine if the "first-pass effect" is an independent predictor of favorable outcomes in anterior circulation stroke.

Main Methods:

  • Compared clinical outcomes of 164 patients with complete reperfusion (mTICI 3) after one pass (n=62) versus multiple passes (n=102).
  • Utilized multivariable and case-control analyses, including matched cohorts, to adjust for confounding factors like time to reperfusion and clot location.

Main Results:

  • First-pass complete reperfusion showed a significant association with favorable clinical outcomes (P=0.013).
  • Matched cohorts demonstrated nearly double the rate of favorable outcomes in the first-pass group (62-67% vs. 36-37%).
  • Odds for favorable outcomes were 2.4 to 3.2 times higher with first-pass reperfusion.

Conclusions:

  • Complete reperfusion during the first pass of mechanical thrombectomy is an independent predictor of favorable outcomes in stroke patients.
  • The "first-pass effect" should be a primary goal in mechanical thrombectomy procedures to maximize patient recovery.