Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

26.9K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
26.9K
Telomeres and Telomerase02:41

Telomeres and Telomerase

7.1K
7.1K
Transcription01:10

Transcription

155.8K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
155.8K
Transcription Factors02:16

Transcription Factors

82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

10.9K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
10.9K
Master Transcription Regulators02:23

Master Transcription Regulators

7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ROLE OF TELOMERIC PROTEIN COMPLEX AND TELOMERIC RNA IN EARLY DEVELOPMENT OF DROSOPHILA.

Tsitologiia·2018
Same author

Interaction of Telomeric Retroelement HeT-A Transcripts and Their Protein Product Gag in Early Embryogenesis of Drosophila.

Biochemistry. Biokhimiia·2016
Same author

Functional significance of the human nucleolar protein SURF6, the key member of the SURF6 protein family in eukaryotes.

Doklady. Biochemistry and biophysics·2014
Same author

piRNA clusters as a main source of small RNAs in the animal germline.

Biochemistry. Biokhimiia·2013
Same author

Structure of telomeric chromatin in Drosophila.

Biochemistry. Biokhimiia·2007
Same author

[RNA binding proteins in the RNA interference phenomenon].

Molekuliarnaia biologiia·2006

Related Experiment Video

Updated: Jan 23, 2026

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

7.8K

Nature and Functions of Telomeric Transcripts.

M Yu Kordyukova1, A I Kalmykova2

  • 1Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.

Biochemistry. Biokhimiia
|June 21, 2019
PubMed
Summary

Telomeric RNAs are vital components of telomeres, regulating telomere length and genomic stability. These transcripts play a critical role in protecting telomeres and signaling their status to cellular genes.

More Related Videos

Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.6K
Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

3.0K

Related Experiment Videos

Last Updated: Jan 23, 2026

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells
09:13

Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells

Published on: January 17, 2019

7.8K
Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.6K
Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

3.0K

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Telomeres are crucial for maintaining genomic stability.
  • Telomeric transcripts (TERTs) are integral components of telomeres.
  • TERTs are implicated in regulating telomere length, chromatin formation, and replication.

Purpose of the Study:

  • To investigate the role of telomeric RNAs in early Drosophila development.
  • To elucidate the regulatory functions of telomeric RNAs in genomic stability.
  • To understand the mechanisms of telomeric RNA-mediated signaling pathways.

Main Methods:

  • Analysis of the telomeric transcriptome in early Drosophila embryos.
  • Investigating the interaction of telomeric transcripts with cellular proteins.
  • Studying the translocation of telomeric transcripts within the cell.

Main Results:

  • Telomeric RNAs were found to regulate genomic stability in Drosophila.
  • These transcripts interact with multiple proteins and translocate within the cell.
  • A novel level of genomic stability regulation involving telomeric RNAs was identified.

Conclusions:

  • Telomeric RNAs are critical for telomere protection and function.
  • Telomeric transcripts act as signaling molecules, conveying telomere status to cellular genes.
  • Further research is needed to fully understand telomeric RNA signaling pathways at the organism level.