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Functionalized MoS2-erlotinib produces hyperthermia under NIR.

Chen Zhang1, Doudou Zhang2, Jian Liu2

  • 1Institute of Oceanography, Minjiang University, Wucheng Building, 5FL, No.200 Xiyuangong Road, Fuzhou, 350108, Fujian, China.

Journal of Nanobiotechnology
|June 21, 2019
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Summary

This study presents a novel molybdenum disulfide (MoS2)-based nanoplatform for targeted cancer therapy. The system delivers chemotherapy drugs and uses near-infrared light for photothermal treatment, showing enhanced efficacy against lung cancer cells.

Keywords:
Drug deliveryMoS2Synergistic chemo-photothermal therapyTargeted

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Molybdenum disulfide (MoS2) exhibits excellent photothermal conversion properties, making it suitable for biomedical applications.
  • Developing effective drug delivery systems is crucial for cancer therapy.

Purpose of the Study:

  • To create a multifunctional MoS2-based drug delivery system (MoS2-SS-HA) for targeted cancer treatment.
  • To combine chemotherapy and photothermal therapy into a single nanocarrier system.

Main Methods:

  • Decorating MoS2 nanosheets with hyaluronic acid (HA) to create tumor-targeting capabilities.
  • Loading the nanocarrier with the anti-cancer drug erlotinib (Er).
  • Utilizing near-infrared (NIR) laser irradiation to trigger drug release and induce photothermal effects.

Main Results:

  • The MoS2-SS-HA nanocomposites demonstrated good biocompatibility, stability, and controlled drug release upon NIR irradiation.
  • The nanoplatform selectively targeted and eliminated CD44-positive lung cancer cells, including drug-resistant strains.
  • In vivo studies confirmed a superior synergistic therapeutic effect from the combined chemo-photothermal treatment.

Conclusions:

  • The developed MoS2 nanoplatform is a promising system for targeted drug delivery.
  • This system offers a potent approach for synergistic chemo-photothermal cancer therapy.