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Ir gene for bovine insulin in the rat maps to RT1.B beta
K Mizuno1, T Inomata, S Tsuchimoto
1Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Journal of Immunogenetics
|April 1, 1987
Abstract:
The genetic control of the immune response to bovine insulin (BI) in the rat was investigated. As a result of experiments utilizing two intra-MHC recombinant rats and of blocking experiments with monoclonal antibodies against MHC class II antigens, an immune response gene for BI in the rat could be mapped to the RT1.B beta locus.