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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Development of Compendium for Esophageal Squamous Cell Carcinoma

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The analyses of SRCR genes based on protein-protein interaction network in esophageal squamous cell carcinoma

Zepeng Du1,2, Qiaoxi Xia3, Bingli Wu3

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Genes Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou 510120, China.

American Journal of Translational Research
|June 21, 2019
PubMed

Insights

Scavenger receptor cysteine-rich (SRCR) proteins are implicated in esophageal squamous cell carcinoma (ESCC). This study identifies key SRCR genes and their network, revealing their potential as prognostic factors and therapeutic targets in ESCC.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Scavenger receptor cysteine-rich (SRCR) proteins, characterized by SRCR domains, are crucial in human diseases.
  • The specific roles of SRCR proteins in esophageal squamous cell carcinoma (ESCC) are not fully understood.

Purpose of the Study:

  • To elucidate the functions of SRCR proteins in ESCC.
  • To identify differentially-expressed SRCR genes and construct their biological network.
  • To evaluate the prognostic significance of SRCR genes in ESCC.

Main Methods:

  • Sequence alignment and phylogenetic analysis of human SRCR domains.
  • Identification of differentially-expressed SRCR genes in ESCC.
  • Protein-protein interaction (PPI) network construction and analysis.
  • Functional enrichment and survival analyses (Kaplan-Meier curves).

Main Results:

  • Variations in conserved cysteines suggest a need for SRCR family reclassification.
  • Ten SRCR genes (LGALS3BP, MSR1, CD163, LOXL2, LOXL3, LOXL4, DMBT1, PRSS12, TMPRSS2, SCARA5) showed differential expression in ESCC.
  • The SRCR gene network is linked to extracellular structure organization and the PI3K-Akt signaling pathway.
  • High expression of SCARA5, LOXL2, LOXL3, LOXL4 correlated with poor survival, while high DMBT1 and PRSS12 expression indicated better survival.

Conclusions:

  • SRCR genes and their network significantly influence ESCC development.
  • These SRCR genes represent potential prognostic biomarkers for ESCC.
  • The SRCR gene network offers potential therapeutic targets for ESCC treatment.
Keywords:
SRCR geneesophageal squamous cell carcinomafunctional enrichmentprotein-protein interaction networksequence analysis

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