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Relationship between circulating concentration of Ang II, ADM and ADT and left ventricular hypertrophy in

Yameng Cui1, Zhenyu Zhu1, Xin Qi2

  • 1School of Graduate Studies, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.

American Journal of Translational Research
|June 21, 2019
PubMed

Insights

Plasma levels of angiotensin II (Ang II) and Adrenomedulin (ADM) are elevated in hypertensive patients with left ventricular hypertrophy (LVH). These, along with adrenotensin (ADT), may help identify LVH in hypertension.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarker Discovery

Background:

  • Left ventricular hypertrophy (LVH) is a common complication of hypertension and a significant predictor of cardiovascular events.
  • Understanding the molecular mechanisms underlying LVH in hypertension is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the relationship between plasma concentrations of angiotensin II (Ang II), Adrenomedulin (ADM), and adrenotensin (ADT) in patients with hypertension and LVH.
  • To explore the potential of these peptides as biomarkers for identifying hypertensive LVH.

Main Methods:

  • A cohort of 310 hypertensive patients and 39 healthy controls were analyzed.
  • Left ventricular hypertrophy was determined based on LVMI criteria from the 2013 ESC Hypertension Management Guidelines.
  • Plasma levels of Ang II, ADM, and ADT were quantified using ELISA assays.

Main Results:

  • Plasma Ang II and ADM levels were significantly higher in hypertensive patients compared to controls, and further elevated in those with LVH.
  • LVMI showed a positive correlation with Ang II and ADM, and a negative correlation with ADT.
  • Systolic blood pressure, Ang II, ADM, and ADT were strongly associated with LVH, with ADM and ADT demonstrating similar diagnostic value.

Conclusions:

  • Plasma Ang II, ADM, and ADT levels may serve as valuable indicators for identifying left ventricular hypertrophy in hypertensive individuals.
  • These findings contribute to the understanding of the pathophysiological role of these peptides in hypertensive heart disease.
Abstract

Keywords:
Hypertensionadrenomedulinadrenotensinangiotensin IIleft ventricular hypertrophy

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