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Challenges and solutions in patient treatment strategies for stage II colon cancer
Susan Fotheringham1, Guy A Mozolowski1, Eleanor M A Murray2
1Oxford Cancer Biomarkers Limited, The Magdalen Centre, The Oxford Science Park, Robert Robinson Avenue, Oxford, UK.
Abstract:
Colorectal cancer remains one of the most common cancers worldwide and, despite improvements in treatment options for late-stage metastatic cancer, there are still questions surrounding how best to treat early-stage disease patients. Some recent advances have been made in the staging of cancer and improving the risk assessment of strategies for patient treatment. A number of high-risk features have been proposed that may help to stratify stage II cancer patients into groups that will truly benefit from adjuvant chemotherapy. Diagnostic tests are becoming available to measure these biomarkers, utilizing both currently available and novel technologies. This review will describe the challenges in treatment decisions for early-stage colon cancer and how personalized medicine can assist clinicians in making the best treatment choices for patients with stage II colon cancer in particular.
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