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Related Experiment Videos

Small intestinal permeability in pediatric clinical practice.

I Hamilton1, A Hill, B Bose

  • 1Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.

Journal of Pediatric Gastroenterology and Nutrition
|September 1, 1987
PubMed
Summary

This study shows a sugar absorption test accurately detects intestinal disease in children. It found higher lactulose/mannitol ratios in children with coeliac disease or milk intolerance, indicating abnormal gut permeability.

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Area of Science:

  • Pediatric Gastroenterology
  • Intestinal Permeability Studies
  • Diagnostic Testing

Background:

  • Assessing small intestinal permeability is crucial for diagnosing pediatric gastrointestinal disorders.
  • Previous methods for evaluating intestinal function in children can be invasive or difficult to implement in routine practice.

Purpose of the Study:

  • To evaluate the utility of a hypertonic differential sugar absorption test for assessing passive small intestinal permeability in children.
  • To compare the lactulose/mannitol recovery ratio in children with suspected intestinal disease versus healthy controls.

Main Methods:

  • A hypertonic differential sugar absorption test using lactulose and mannitol was administered orally to children.
  • Urinary recovery of both sugars was measured to calculate the lactulose/mannitol recovery ratio.

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  • Results were compared between children with diagnosed coeliac disease, cows' milk intolerance, normal jejunal biopsies, and other conditions.

    • Main Results:

    • Children with coeliac disease and cows' milk intolerance exhibited an elevated urinary lactulose/mannitol recovery ratio.
    • This elevated ratio was primarily due to a reduced urinary recovery of mannitol.
    • The test was well-tolerated by young children and demonstrated abnormal intestinal function.

    Conclusions:

    • The hypertonic differential sugar absorption test is a safe, practical, and effective method for diagnosing intestinal disease in children.
    • This test can identify abnormal small intestinal permeability, particularly reduced mannitol absorption, in pediatric patients.
    • It offers a valuable tool for routine clinical pediatric practice in diagnosing gastrointestinal disorders.