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Updated: Jan 23, 2026
07:30
Electromagnetic Navigation Transthoracic Nodule Localization for Minimally Invasive Thoracic Surgery
Published on: May 4, 2022
3.7K
[Hyperthermic intrathoracic chemotherapy in thoracic surgery]
H-S Hofmann1,2, M Ried3
1Klinik für Thoraxchirurgie, Krankenhaus Barmherzige Brüder Regensburg, Prüfeningerstraße 86, 93049, Regensburg, Deutschland. hans-stefan.hofmann@barmherzige-regensburg.de.
Summary
Hyperthermic intrathoracic chemotherapy (HITOC) offers improved local tumor control for pleural cancers like mesothelioma. This approach, combined with surgery and cisplatin, aims to extend survival and reduce recurrence rates.
Area of Science:
- Oncology
- Surgical Oncology
- Chemotherapy
Background:
- Regional chemotherapy of the pleural space includes intrapleural hyperthermic perfusion (IHP) and hyperthermic intrathoracic chemotherapy (HITOC).
- HITOC is an additive procedure following surgical cytoreduction for pleural tumors.
Purpose of the Study:
- To evaluate the efficacy of HITOC in managing pleural malignancies.
- To highlight indications, chemotherapeutic agents, and perioperative management for HITOC.
Main Methods:
- HITOC is performed after surgical cytoreduction.
- Cisplatin is the standard agent at 150-175 mg/m² body surface area.
- Adapted perioperative management is crucial for minimizing complications.
Main Results:
- HITOC is indicated for malignant pleural mesothelioma and thymoma with pleural spread (Stage IVa).
- Treatment of secondary pleural carcinomatosis is selective.
- Minimizing complications like renal insufficiency is achievable with proper management.
Conclusions:
- HITOC aims to enhance local tumor control in pleural malignancies.
- The goal is to achieve longer recurrence-free and overall survival.
- Strict safety measures are essential for personnel protection.
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