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Published on: May 19, 2020
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User-dependent variability in mitral valve segmentation and its impact on CFD-computed hemodynamic parameters.
Katharina Vellguth1, Jan Brüning2, Lennart Tautz2,3
1Charité - Universitätsmedizin Berlin, Berlin, Germany. katharina.vellguth@charite.de.
Summary
User variability in mitral valve segmentation introduces errors comparable to clinical measurement variations. Further research is needed to understand the relationship between anatomical features and blood flow dynamics.
Area of Science:
- Medical imaging analysis
- Computational fluid dynamics
- Cardiovascular research
Background:
- Mitral valve segmentation is crucial for computational fluid dynamics (CFD) simulations supporting treatment.
- Current segmentation tools often require manual user input, introducing variability.
- Quantifying this user-dependency is vital for assessing the reliability of CFD simulations.
Purpose of the Study:
- To investigate the inter-user variability in geometric parameters of mitral valve segmentation.
- To analyze how this variability propagates into numerically calculated hemodynamics.
- To assess the impact of user-dependent segmentation errors on simulation reliability.
Main Methods:
- Evaluated inter-user variability of projected orifice area (OA) and projected annulus area (AA) in 10 mitral valve geometries.
- Each geometry was segmented by three independent users.
- Investigated the propagation of geometric variations into blood flow velocity calculations.
Main Results:
- Annulus area (AA) showed the least user-dependency, with deviations typically under 10%.
- Orifice area (OA) exhibited larger user-dependent variations.
- Variations in calculated hemodynamics were similar in magnitude to geometric parameter variations.
- No correlation was found between geometric parameter variations and hemodynamic parameter variations.
Conclusions:
- User-dependent segmentation errors are comparable in scale to variations in calculated hemodynamics.
- These errors are also similar to variations observed in clinical Doppler echocardiography measurements.
- The lack of correlation highlights the need for further investigation into the complex interplay between mitral valve anatomy and blood flow.
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