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Pharmacologic modification of psychosexual dysfunction.

T L Crenshaw1, J P Goldberg, W C Stern

  • 1Crenshaw Clinic, San Diego, CA 92109.

Journal of Sex & Marital Therapy
|January 1, 1987
PubMed
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Bupropion hydrochloride significantly improved libido and overall sexual functioning in patients with psychosexual dysfunction. This study provides the first evidence of pharmacologic treatment improving psychological aspects of sexual dysfunction in a controlled trial.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Sexual Medicine

Background:

  • Psychosexual dysfunction encompasses various conditions like inhibited sexual desire and orgasm.
  • Effective pharmacological treatments for psychosexual dysfunction, particularly its psychological components, remain an area of significant need.

Purpose of the Study:

  • To evaluate the efficacy of bupropion hydrochloride compared to placebo in treating psychosexual dysfunction.
  • To assess the impact of bupropion on libido, sexual excitement, orgasm, and overall sexual functioning.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 60 outpatients with psychosexual dysfunction.
  • An initial 8-week single-blind placebo phase to establish baseline and identify placebo responders.
  • Subsequent 12-week double-blind treatment with bupropion hydrochloride (225-450 mg/day) or placebo.

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Main Results:

  • Bupropion treatment led to significantly greater improvements in libido and global sexual functioning assessments after 12 weeks.
  • 63% of patients on bupropion reported substantial improvement compared to only 3% on placebo.
  • While trends towards increased sexual activity were observed, changes in frequency were less pronounced.

Conclusions:

  • Bupropion hydrochloride demonstrates efficacy in improving psychological aspects of sexual dysfunction, including libido.
  • This study represents a key advancement, offering the first controlled trial evidence for pharmacologic improvement in psychosexual dysfunction.
  • Further research may explore bupropion's role in enhancing sexual behavior frequency.