Analytical comparison between two hematological analyzer systems: Mindray BC-5180 vs Sysmex XN-1000

Area of Science:

• Hematology
• Clinical Diagnostics
• Laboratory Instrumentation

Background:

• External quality assessment (EQA) is crucial for ensuring laboratory test accuracy.
• Comparing different hematology analyzers is essential for reliable diagnostic results.

Purpose of the Study:

• To compare the performance of Mindray BC-5180 and Sysmex XN-1000 hematology analyzers.
• To evaluate the agreement of complete blood count (CBC) results between these two instruments using EQA data.

Main Methods:

• Analysis of CBC results from 72 laboratories participating in the 2018 Shandong Province EQA program.
• Statistical methods included t-tests, Passing-Bablok regression, and Bland-Altman analysis.
• Key parameters analyzed: White Blood Cell (WBC), Red Blood Cell (RBC), Hemoglobin (Hb), Platelet (PLT), and Hematocrit (HCT).

Main Results:

• No significant differences in average results between Mindray BC-5180 and Sysmex XN-1000 (P > 0.05).
• High correlation (r > 0.98) and good agreement observed, with Passing-Bablok regression showing intercepts near 0 and slopes near 1.
• Bland-Altman analysis confirmed over 95% of results within consistency limits, with clinically acceptable differences for all measured parameters.

Conclusions:

• The Mindray BC-5180 and Sysmex XN-1000 demonstrate strong correlation and consistency in CBC testing.
• The two hematology analyzers are considered interchangeable, offering reliable performance in clinical settings.