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Alternative RNA Splicing

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Related Experiment Video

Updated: Jan 23, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella

Published on: November 30, 2018

Alternative splicing and insect ryanodine receptor.

Surajit De Mandal¹, Muhammad Shakeel¹, Vasantha Srinivasan Prabhakaran²

¹Laboratory of Bio-Pesticide Creation and Application of Guangdong Province, College of Agriculture, Department of Entomology, South China Agricultural University, Guangzhou, People's Republic of China.

Archives of Insect Biochemistry and Physiology

|June 21, 2019

Summary

This study presents a phylogenetic tree for the ryanodine receptor (RyR) family. Maximum likelihood estimation was used to analyze evolutionary relationships among RyR proteins.

Keywords:

alternative splicing calcium channels evolutionary mechanisms ryanodine receptors signaling

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Last Updated: Jan 23, 2026

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Area of Science:

Evolutionary biology
Molecular biology
Genomics

Background:

The ryanodine receptor (RyR) family comprises critical calcium channels involved in muscle contraction and intracellular calcium signaling.
Understanding the evolutionary history of RyRs is essential for deciphering their functional diversification and roles across different species.

Purpose of the Study:

To construct a comprehensive phylogenetic tree of the ryanodine receptor (RyR) family.
To elucidate the evolutionary relationships and diversification patterns within the RyR gene family.

Main Methods:

Phylogenetic analysis using maximum likelihood estimation.
Sequence data collection for various RyR family members across diverse taxa.
Tree reconstruction and statistical support assessment.

Main Results:

The phylogenetic tree reveals distinct clades corresponding to major RyR subfamilies.
Evolutionary divergence patterns suggest gene duplication events shaped the RyR family.
Specific RyR isoforms show conserved evolutionary trajectories.

Conclusions:

The constructed phylogenetic tree provides a robust framework for studying RyR evolution.
This evolutionary perspective aids in understanding the functional specialization of RyR channels.
Further research can leverage this phylogeny to investigate RyR-related diseases and functions.