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Development of a new diaper dermatitis-like reconstructed skin equivalent for testing children atopic dermatitis

Linyi Zhuang1, Hongjian Gu1, Yu Huang1

  • 1Pigeon Manufacturing Shanghai Co., Ltd., Shanghai, China.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|June 21, 2019
PubMed

Insights

A new in vitro model using reconstructed human skin effectively mimics diaper dermatitis. This model helps evaluate formulas that reduce inflammation and improve skin barrier function, offering relief for diaper rash symptoms.

Area of Science:

  • Dermatology
  • In vitro skin models
  • Inflammatory skin conditions

Background:

  • Diaper dermatitis (DD) is a prevalent inflammatory skin condition impacting children and families.
  • Existing treatments focus on symptom relief, necessitating better screening methods.
  • Developing reliable in vitro models is crucial for evaluating therapeutic interventions.

Purpose of the Study:

  • To create and validate an in vitro reconstructed human skin equivalent for diaper dermatitis.
  • To screen and assess the efficacy of different topical formulas in alleviating DD symptoms.
  • To evaluate the anti-inflammatory and skin barrier repair potential of tested formulations.

Main Methods:

  • A diaper dermatitis-like human skin equivalent was developed using 0.2% Sodium lauryl sulfate (SLS).
  • The model exhibited key DD characteristics: elevated interleukin-1α (IL-1α) and compromised skin barrier.
  • Four anti-inflammatory and barrier-promoting formulas were applied topically and assessed for IL-1α levels, tissue viability, and barrier function.

Main Results:

  • SLS successfully induced inflammation, reduced tissue viability, and impaired skin barrier function in the skin equivalent.
  • A cream formulation demonstrated significant efficacy in mitigating SLS-induced irritation.
  • Tested cream reduced IL-1α levels and improved tissue viability compared to placebo.

Conclusions:

  • The SLS-induced reconstructed human skin equivalent accurately replicates the inflammatory response seen in diaper dermatitis.
  • This in vitro model serves as a valuable tool for evaluating the efficacy of diaper dermatitis treatments.
  • The study highlights the potential of specific formulations in managing diaper dermatitis symptoms.
Abstract

Keywords:
Diaper dermatitisanti-inflammationreconstructed human skin equivalent in vitroskin barrier

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