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STAT3: A Potential Drug Target for Tumor and Inflammation

Yang Sheng Hu1, Xu Han1, Xin Hua Liu1

  • 1School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, 230032, China.

Current Topics in Medicinal Chemistry
|June 21, 2019
PubMed

Insights

Signal Transducers and Activators of Transcription 3 (STAT3) is crucial in cell regulation, inflammation, and cancer. This review details STAT3

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Oncology

Background:

  • Signal Transducers and Activators of Transcription (STAT) proteins regulate cellular activities.
  • STAT3 is implicated in normal cell functions like differentiation and proliferation.
  • Aberrant STAT3 activation is linked to tumor growth and inflammatory processes.

Purpose of the Study:

  • To review the extensive research on STAT3.
  • To highlight STAT3's dual role in inflammation and cancer.
  • To discuss STAT3 as a therapeutic target.

Main Methods:

  • Literature review of STAT3 research.
  • Analysis of STAT3's involvement in cellular processes.
  • Examination of STAT3's role in disease pathogenesis.

Main Results:

  • STAT3 promotes tumor growth and proliferation when highly expressed in cancer cells.
  • STAT3 plays a significant role in anti-inflammatory responses and tissue repair.
  • Over 20 years of research have established STAT3's importance.

Conclusions:

  • STAT3 is a key regulator in both normal physiology and disease.
  • STAT3 is a validated therapeutic target, with small molecule inhibitors developed.
  • This review consolidates current knowledge on STAT3's multifaceted roles.
Keywords:
Anti-tumorFunctionInflammationInhibitorSTAT 3Target.

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