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Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality.
Jiaqi Huang1, Stephanie J Weinstein1, Kai Yu1
1From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (J.H., S.J.W., K.Y., D.A.).
Circulation Research
|June 21, 2019
Summary
Higher vitamin E levels in the blood are linked to a lower risk of death from all causes and major diseases. This study highlights the long-term health benefits of adequate vitamin E status.
Area of Science:
- Biochemistry and Human Health
- Nutritional Epidemiology
- Gerontology
Background:
- Vitamin E's health effects are of long-standing interest.
- A comprehensive analysis of circulating vitamin E and long-term mortality is lacking.
Purpose of the Study:
- To determine the association between serum alpha-tocopherol (vitamin E) and long-term mortality.
- To elucidate dose-response relationships and quantify these associations.
Main Methods:
- Biochemical analysis of serum alpha-tocopherol in 29,092 participants of the ATBC Study.
- 30-year follow-up to identify 23,787 deaths from various causes.
- Statistical analysis adjusting for major risk factors.
Main Results:
- Higher serum alpha-tocopherol was significantly associated with lower all-cause mortality (HRs 0.75-0.83).
- Significant reductions in mortality from cardiovascular disease, cancer, and respiratory disease were observed.
- Associations were modified by baseline age and body mass index.
Conclusions:
- Higher baseline serum alpha-tocopherol is linked to reduced overall and cause-specific mortality.
- Data support long-term health benefits of adequate vitamin E status.
- Replication in diverse populations is recommended.
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