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Author Spotlight: Studying Behavior of Acanthamoeba to Develop Targeted Strategies for Preventing Acanthamoeba Keratitis
Published on: September 20, 2024
Corneal Endotheliitis as a Presentation of Acanthamoeba Keratitis
Chih-Wei Hsu1, Chun-Hsiu Liu, Ching-Hsi Hsiao
1Department of Education (C.-W.H.), Chang Gung Memorial Hospital, Linkou, Taiwan; College of Medicine (C.-H.L., C.-H.H.), Chang Gung University, Taoyuan, Taiwan; and Department of Ophthalmology (C.-H.L., C.-H.H.), Chang Gung Memorial Hospital, Linkou, Taiwan.
Objective:
To report 2 cases of Acanthamoeba keratitis (AK) presenting with corneal endotheliitis.
Methods:
Case report.
Results:
Two contact lens wearers, who had been diagnosed with herpes simplex virus (HSV) keratitis, predominantly manifested corneal endotheliitis composed of corneal edema, keratic precipitates, and anterior chamber reaction at referral. AK was confirmed using cultures or through polymerase chain reaction testing. The patients were started on polyhexamethylene biguanide and responded favorably to regain satisfactory visual acuity.
Conclusions:
Corneal endotheliitis, although uncommon, may be a manifestation of AK. We must have high-index suspicion for AK in all contact lens users, particularly before making a diagnosis of HSV keratitis. Accurate diagnosis and prompt treatment can result in a favorable prognosis for AK.
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