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Updated: Jan 23, 2026
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Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
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LAG3 in Solid Tumors as a Potential Novel Immunotherapy Target.
Su Jin Lee1,2, Sun-Ju Byeon3, Jeeyun Lee1
1Department of Medicine, Division of Hematology-Oncology.
Journal of Immunotherapy (Hagerstown, Md. : 1997)
|June 21, 2019
Summary
Lymphocyte activation gene 3 (LAG3) was expressed in 18.5% of advanced cancers, notably pancreatic and gastric. Further clinical research into LAG3 as an immunotherapy target is warranted.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Lymphocyte-activation gene 3 (LAG3) is an emerging immune checkpoint inhibitor.
- Understanding LAG3 expression patterns across diverse advanced cancers is crucial for developing novel immunotherapies.
Purpose of the Study:
- To prospectively analyze the expression of LAG3 in a cohort of patients with advanced gastrointestinal, genitourinary, and rare cancers.
- To investigate the correlation of LAG3 expression with clinical and molecular characteristics in metastatic colorectal and gastric cancers.
Main Methods:
- Prospective immunohistochemical analysis of LAG3 expression in 430 patients with advanced cancers.
- Evaluation of LAG3 expression in relation to clinicopathological factors and molecular markers (KRAS, NRAS, BRAF, MSI, EBV) in specific cancer types.
Main Results:
- LAG3 was expressed in 18.5% of evaluated advanced cancers.
- Highest LAG3 expression observed in pancreatic (33.3%) and gastric (24.7%) cancers.
- In metastatic gastric cancer, LAG3 expression was significantly associated with Epstein-Barr virus (EBV) status (P=0.042).
- No significant associations found between LAG3 status and clinicopathological or molecular features in metastatic colorectal cancer.
Conclusions:
- LAG3 is expressed across a spectrum of advanced cancers, with notable prevalence in pancreatic and gastric malignancies.
- The association with EBV status in gastric cancer suggests potential context-specific roles for LAG3.
- These findings support further clinical investigation of LAG3 as a therapeutic target in immunotherapy for various advanced cancers.
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