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Complex patterns of subcellular cardiac alternans.

Joshua Veasy1, Yi Ming Lai1, Stephen Coombes1

  • 1Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

Journal of Theoretical Biology
|June 21, 2019
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Summary
This summary is machine-generated.

Microscopic cardiac alternans, an early sign of arrhythmia, emerge differently based on calcium diffusion. Luminal coupling reveals a novel pathway to alternans, highlighting its role in cardiac calcium dynamics.

Keywords:
Cytosolic and luminal calcium diffusionIntracellular calcium dynamicsNetwork dynamicsSynchrony

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Area of Science:

  • Cardiovascular physiology
  • Computational biology
  • Biophysics

Background:

  • Cardiac alternans precede fatal arrhythmias like sudden cardiac death.
  • Microscopic alternans are early indicators, preceding fully developed alternans.
  • Understanding alternans onset is crucial for preventing cardiac events.

Purpose of the Study:

  • To model and investigate microscopic calcium alternans.
  • To explore the impact of calcium diffusion on alternans formation.
  • To identify novel mechanisms driving cardiac alternans.

Main Methods:

  • Developed a computational model for intracellular calcium dynamics.
  • Investigated effects of cytosolic and sarcoplasmic reticulum calcium diffusion.
  • Employed semi-analytical and computational techniques to analyze stability regions.

Main Results:

  • Cytosolic coupling leads to alternans via period doubling bifurcation.
  • Luminal coupling results in a novel saddle-node bifurcation pathway.
  • Emergent calcium patterns change abruptly at stability boundaries.

Conclusions:

  • Microscopic calcium alternans exhibit complex dynamics.
  • Luminal calcium plays a significant role in cardiac calcium dynamics.
  • This study reveals new insights into the origins of cardiac alternans.