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Analysis of FAM19A2/TAFA-2 function.

Junichi Okada1, Eijiro Yamada2, Tsugumichi Saito2

  • 1Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.

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|June 21, 2019
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Summary

The chemokine FAM19A2/TAFA-2 influences eating behavior and metabolism. Studies show it increases food intake and energy expenditure in mice, suggesting a role in metabolic regulation.

Keywords:
Body temperatureFAM19A2/TAFA-2Food intakeMetabolic cage

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Area of Science:

  • Neuroendocrinology
  • Metabolic regulation
  • Chemokine signaling

Background:

  • FAM19A2/TAFA-2 is a chemokine with sequence similarity to MIP-1α, a molecule affecting body temperature and appetite.
  • Chemokines are implicated in various physiological processes, including energy balance.

Purpose of the Study:

  • To investigate the role of FAM19A2/TAFA-2 in the regulation of food intake and metabolic activity.
  • To determine the effects of FAM19A2/TAFA-2 administration on feeding patterns and energy expenditure in mice.

Main Methods:

  • Administration of FAM19A2/TAFA-2 to the third ventricle of mice.
  • Monitoring of food intake, meal parameters (size, number), respiratory exchange rate, energy expenditure, and physical activity (ambulatory count, vertical activity).

Main Results:

  • FAM19A2/TAFA-2 administration significantly increased food intake and meal number during the dark period.
  • Meal size was reduced, while respiratory exchange rate and energy expenditure were significantly increased.
  • No significant effects were observed on ambulatory count or vertical activity.

Conclusions:

  • FAM19A2/TAFA-2 plays a role in the central regulation of food intake.
  • FAM19A2/TAFA-2 influences metabolic rate and energy expenditure.
  • These findings highlight FAM19A2/TAFA-2 as a potential regulator of energy homeostasis.