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Liquidambar styraciflua L.: A new potential source for therapeutic uses.
Graziele Francine Franco Mancarz1, Laressa Carolina Laba2, Elaine Cristina Pinto da Silva2
1Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, PR, Brazil.
Journal of Pharmaceutical and Biomedical Analysis
|June 21, 2019
Summary
Liquidambar styraciflua L. exhibits significant anti-inflammatory properties and synergistic effects with antibiotics against bacteria. Phytochemical analysis reveals rich phenolic compounds, supporting its potential as a therapeutic agent.
Area of Science:
- Phytochemistry
- Pharmacology
- Natural Products
Background:
- Liquidambar styraciflua L. (sweet gum) is traditionally used for various ailments.
- Its biological potential and chemical composition remain underexplored.
Purpose of the Study:
- To investigate the chemical profile and biological activities of Liquidambar styraciflua L. extracts.
- To evaluate its anti-inflammatory, cytotoxic, and synergistic effects with antibiotics.
Main Methods:
- Phytochemical analysis using liquid chromatography-mass spectrometry.
- Spectrophotometric assays for phenolics, flavonoids, and tannins.
- Enzyme inhibition assay for anti-inflammatory activity.
- MTT assay for cytotoxicity.
- Checkerboard assay for antibiotic synergy.
Main Results:
- Extracts are rich in phenolics, flavonoids, and tannins.
- Stem extracts demonstrated potent anti-inflammatory activity, outperforming commercial propolis.
- Synergistic activity observed with tetracycline against Staphylococcus aureus and Enterococcus faecalis.
- Low toxicity and moderate cytotoxicity noted for stem extracts.
Conclusions:
- Liquidambar styraciflua L. possesses significant anti-inflammatory potential.
- The plant exhibits synergistic interactions with antibiotics, suggesting novel therapeutic applications.
- Further research is warranted to explore its medicinal value.
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