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Probiotic Studies in Neonatal Mice Using Gavage
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Topical probiotics: the unknowns behind their rising popularity
Griffin R Lee, Melody Maarouf, Aleksi J Hendricks
1Division of Dermatology, Department of Medicine, University of Arizona, Tucson, AZ. versushi@email.arizona.edu.
Dermatology Online Journal
|June 21, 2019
Summary
Topical probiotics show promise for skin conditions like acne and rosacea, but more research is needed on their safety and effectiveness. Current regulations also present gaps for these popular skincare products.
Area of Science:
- Dermatology and Microbiology
- Cosmeceuticals and Regulatory Science
Background:
- Topical probiotics have a long history in skincare, with a recent surge in commercial availability.
- Despite widespread use, significant clinical and regulatory gaps persist regarding their application.
Purpose of the Study:
- To systematically review clinical data on topical probiotics.
- To identify existing clinical and regulatory gaps in the field.
Main Methods:
- Conducted systematic searches of PubMed and Google Scholar for relevant trials and reviews.
- Reviewed U.S. Food and Drug Administration (FDA) definitions and regulations for cosmetics and drugs.
Main Results:
- Limited trials suggest topical probiotics are effective for acne, atopic dermatitis, and rosacea.
- There is a lack of comprehensive data on safety profiles, mechanisms of action, and therapeutic potential.
- The FDA has not approved any topical probiotic products as drugs, highlighting regulatory inconsistencies.
Conclusions:
- Increasing public interest in topical probiotics is not matched by robust clinical evidence or a full understanding of side effects.
- Further research into mechanisms, clinical efficacy, and safety is essential.
- Improved regulation and standardization are necessary for topical probiotic products.
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