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Updated: Jan 23, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling
Published on: July 4, 2007
Predictive ability of an expert-defined population segmentation framework for healthcare utilization and mortality -
Lian Leng Low1,2, Yu Heng Kwan3,4, Cheryl Ann Ma4
1Department of Family Medicine & Continuing Care, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore. low.lian.leng@singhealth.com.sg.
Background:
Population segmentation of patients into parsimonious and relatively homogenous subgroups or segments based on healthcare requirements can aid healthcare resource planning and the development of targeted intervention programs. In this study, we evaluated the predictive ability of a previously described expert-defined segmentation approach on 3-year hospital utilization and mortality.
Methods:
We segmented all adult patients who had a healthcare encounter with Singapore Health Services (SingHealth) in 2012 using the SingHealth Electronic Health Records (SingHealth EHRs). Patients were divided into non-overlapping segments defined as Mostly Healthy, Stable Chronic, Serious Acute, Complex Chronic without Frequent Hospital Admissions, Complex Chronic with Frequent Hospital Admissions, and End of Life, using a previously described expert-defined segmentation approach. Hospital admissions, emergency department attendances (ED), specialist outpatient clinic attendances (SOC) and mortality in different patient subgroups were analyzed from 2013 to 2015.
Results:
819,993 patients were included in this study. Patients in Complex Chronic with Frequent Hospital Admissions segment were most likely to have a hospital admission (IRR 22.7; p < 0.001) and ED visit (IRR 14.5; p < 0.001) in the follow-on 3 years compared to other segments. Patients in the End of Life and Complex Chronic with Frequent Hospital Admissions segments had the lowest three-year survival rates of 58.2 and 62.6% respectively whereas other segments had survival rates of above 90% after 3 years.
Conclusion:
In this study, we demonstrated the predictive ability of an expert-driven segmentation framework on longitudinal healthcare utilization and mortality.
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