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High-frequency irreversible electroporation for cardiac ablation using an asymmetrical waveform
René van Es1, Maurits K Konings2, Bastiaan C Du Pré1
1Div. Heart and Lungs, Dept. of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
A novel asymmetric, high-frequency waveform for cardiac tissue ablation significantly enhances lesion depth compared to symmetric waveforms. This advancement improves the feasibility of high-frequency irreversible electroporation (HF-IRE) for medical applications.
Area of Science:
- Biomedical Engineering
- Electrophysiology
- Medical Devices
Background:
- Direct current irreversible electroporation (DC-IRE) ablates cardiac tissue but causes muscle contractions and electrolysis-related bubbles.
- High-frequency irreversible electroporation (HF-IRE) offers a solution by minimizing muscle spasms and preventing electrolysis.
Purpose of the Study:
- To introduce and evaluate a novel asymmetric, high-frequency (aHF) waveform for HF-IRE.
- To assess the efficacy of aHF in cardiac tissue ablation through an initial animal study.
Main Methods:
- Development of a novel asymmetric, high-frequency (aHF) waveform.
- Conducting a small-scale animal study to test the aHF waveform's performance in cardiac tissue ablation.
Main Results:
- The aHF waveform generated significantly deeper ablation lesions compared to a symmetric HF waveform.
- This difference in lesion depth was statistically significant (p=0.003) at equivalent energy and frequency levels.
Conclusions:
- The asymmetric, high-frequency (aHF) waveform enhances the feasibility of HF-IRE for cardiac tissue ablation.
- This novel waveform represents a promising advancement in non-thermal ablation techniques.
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