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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
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Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
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Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
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Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

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Target selection for CAR-T therapy.

Jianshu Wei1, Xiao Han1, Jian Bo2

  • 1Molecular & Immunological Department, Bio-therapeutic Department, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing, 100853, China.

Journal of Hematology & Oncology
|June 22, 2019
PubMed
Summary
This summary is machine-generated.

Selecting the right targets is crucial for advancing chimeric antigen receptor T (CAR-T) cell therapy, especially for solid tumors. This review discusses target selection criteria and utilization strategies to improve CAR-T efficacy and safety.

Keywords:
Chimeric antigen receptor-modified T cellsCoverageExpression stabilityOff-tumor effectSpecificityTarget combination

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Area of Science:

  • Immunotherapy
  • Oncology
  • Cellular Therapy

Background:

  • Chimeric antigen receptor T (CAR-T) cell therapy has shown great success in treating blood cancers.
  • Translating CAR-T therapy to solid tumors faces challenges, necessitating careful target selection and utilization.

Purpose of the Study:

  • To review criteria for selecting appropriate targets for CAR-T cell therapy.
  • To discuss novel strategies for utilizing selected targets in CAR-T therapy, particularly for solid tumors.
  • To guide researchers in optimizing target selection for improved CAR-T efficacy and safety in clinical trials.

Main Methods:

  • Systematic review of existing literature on CAR-T therapy target selection.
  • Analysis of criteria for identifying suitable tumor targets.
  • Discussion of innovative strategies for target engagement and CAR-T cell activation.

Main Results:

  • Identified key criteria influencing the success of CAR-T cell therapy based on target selection.
  • Highlighted novel approaches to enhance target recognition and overcome tumor heterogeneity.
  • Emphasized the impact of target choice on both therapeutic efficacy and potential toxicities.

Conclusions:

  • Rational target selection is pivotal for the successful application of CAR-T therapy beyond hematological malignancies.
  • Exploring new target utilization strategies can overcome limitations in treating solid tumors.
  • This review provides a framework for informed target selection in future CAR-T clinical trials.