Related Experiment Video
Updated: Jan 23, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
Effects of immersive virtual reality intervention on pain and anxiety among pediatric patients undergoing
Cho Lee Wong1, Miranda Mei Wa Lui2, Kai Chow Choi3
1The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Room 824, 8/F, Esther Lee Building, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China. jojowong@cuhk.edu.hk.
Insights
Immersive virtual reality (IVR) can reduce pain and anxiety in children during venipuncture. This novel, cost-effective intervention offers procedural information and distraction, improving patient experience and potentially other medical procedures.
Area of Science:
- Pediatric Medicine
- Medical Technology
- Pain Management
Background:
- Venipuncture is a common yet painful procedure for pediatric patients.
- Distraction and age-appropriate information can mitigate procedural pain and anxiety.
- Immersive virtual reality (IVR) offers a unique method for simultaneous distraction and information delivery.
Purpose of the Study:
- To evaluate the effectiveness of IVR intervention in reducing pain, anxiety, and stress during venipuncture in children.
- To assess the impact of IVR on venipuncture duration and healthcare provider satisfaction.
- To compare the cost-effectiveness of IVR intervention against standard care.
Main Methods:
- A randomized controlled trial involving 200 pediatric patients aged 4-12 years.
- The intervention group received age-appropriate IVR modules, while the control group received standard care.
- Outcomes were measured at four time points: before, during, immediately after, and 30 minutes after the procedure.
Main Results:
- (Study results not yet available, as this is a proposal.)
- (Anticipated findings will be analyzed using intention-to-treat and generalized estimating equation models.)
- (Cost-effectiveness analysis will be conducted to compare IVR with standard care.)
Conclusions:
- This study pioneers the use of IVR with procedural information for pediatric venipuncture.
- IVR may offer a novel, accessible, and cost-effective method for managing procedural pain and anxiety.
- Findings could inform the broader application of IVR in other pediatric medical interventions.
Background:
Venipuncture is one of the most painful and distressing procedure experienced by pediatric patients. Evidence suggests that distraction combined with age-appropriate procedural information can effectively decrease procedural pain and anxiety in pediatric patients. Immersive virtual reality (IVR) can simultaneously provide complete distraction and procedural information to patients.
Methods:
Guided by the gate control theory and Lazarus and Folkman's theory, this study aims to examine the effects of IVR intervention on reducing the pain, anxiety and stress, the duration of venipuncture, and the satisfaction of healthcare providers for the procedure. A randomized controlled trial with repeated assessments will be conducted. A total of 200 pediatric patients aged 4-12 years will be recruited from a regional public hospital and randomly assigned to either the intervention or control group. The study will use two age-appropriate IVR modules that consist of procedural information. The intervention group will receive IVR intervention, whereas the control group will receive standard care only. The cost-effectiveness of IVR intervention will be compared with that of standard care. Outcome evaluation will be conducted at four time points: 10 min before, during, immediately after, and 30 min after the procedure. Intention to treat and generalized estimating equation model will be used to analyze the data.
Discussion:
This study is the first of its kind to adopt IVR intervention with age-appropriate procedural information for pediatric patients undergoing venipuncture. Findings of the proposed study may: (1) provide a novel, facile, and cost-effective intervention that can be used virtually at any time and place to manage pain and anxiety; and (2) shed light on the global trends of research and clinical development of IVR as an intervention for other painful and stressful medical procedures.
Trial Registration:
Chinese Clinical Trial Registry, ChiCTR1800018817 . Registered on 11 October 2018.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.

