Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Placebo Effect01:54

The Placebo Effect

6.8K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.8K
Control System Problem01:21

Control System Problem

421
In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
421
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

416
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
416
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
Control Systems01:10

Control Systems

1.8K
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
1.8K
Controller Configurations01:22

Controller Configurations

360
Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation.
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
360

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effects of Intraocular Pressure-Lowering Drops on the Tear Film Assessed by a Novel High-Resolution Tear Film Imager.

Diagnostics (Basel, Switzerland)·2026
Same author

Retinal arteriovenous crossings as spatiotemporal stress fields: a quantitative Doppler OCT flowmetry study.

Scientific reports·2026
Same author

LONG-TERM EFFICACY AND SAFETY OF PHOTOBIOMODULATION IN DRY AGE-RELATED MACULAR DEGENERATION (LIGHTSITE III: 24-MONTH ANALYSIS).

Retina (Philadelphia, Pa.)·2026
Same author

The Sleeping Wolf - Widefield OCT Angiography Revelations of Insidious Systemic Lupus Erythematous-Associated Retinal Vasculitis.

Retinal cases & brief reports·2026
Same author

Subretinal drusenoid deposits are strongly associated with coexistent high-risk vascular diseases.

BMJ open ophthalmology·2026
Same author

Optical coherence tomography and optical coherence tomography angiography in systemic disease.

Taiwan journal of ophthalmology·2025
Same journal

Effect of key baseline disease characteristics on aflibercept 8 mg dosing interval extension: A post hoc 96-week analysis of PULSAR.

Ophthalmology. Retina·2026
Same journal

Congenital Prepapillary Vascular Loops.

Ophthalmology. Retina·2026
Same journal

Lupus Erythematosus Presenting with Ischemic Retinopathy due to Severe Anemia.

Ophthalmology. Retina·2026
Same journal

Bubble Trouble: Preventing Severe Complications after Intraocular Gas Tamponade in Vitreoretinal Surgery.

Ophthalmology. Retina·2026
Same journal

Visual Recovery After Surgery in Epiretinal Membrane Eyes with Retinal Nerve Fiber Layer Schisis and Internal Limiting Membrane Tear.

Ophthalmology. Retina·2026
Same journal

Masquerading disease of macular telangiectasia type 2 - MacTel Project Report No 11.

Ophthalmology. Retina·2026
See all related articles

Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K

Pain Control after Intravitreal Injection Using Topical Nepafenac 0.3% or Pressure Patching: A Randomized,

Richard I Kaplan1, Owen J Drinkwater2, Rachel H Lee1

  • 1Retina Service, Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, New York.

Ophthalmology. Retina
|June 22, 2019
PubMed
Summary
This summary is machine-generated.

Topical nepafenac 0.3% effectively reduced pain after intravitreal injections (IVI) compared to placebo. Patching showed a trend toward pain reduction but did not reach statistical significance.

More Related Videos

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

3.0K
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.6K

Related Experiment Videos

Last Updated: Jan 23, 2026

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.5K
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
03:53

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

3.0K
Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.6K

Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Pain following intravitreal injections (IVI) can persist for up to seven days.
  • This discomfort negatively impacts patient experience and may reduce treatment adherence.

Purpose of the Study:

  • To evaluate the efficacy of topical nepafenac 0.3% suspension and patching in reducing post-IVI pain.
  • To compare these interventions against a placebo control group.

Main Methods:

  • A prospective, randomized, placebo-controlled trial involving sixty patients undergoing IVI.
  • Participants received either nepafenac 0.3%, a pressure patch, or artificial tears (control).
  • Pain was assessed using the Numeric Pain Rating Scale and analyzed nonparametrically.

Main Results:

  • Nepafenac and patching groups reported lower pain scores at 6 and 24 hours compared to the control group.
  • Nepafenac significantly reduced pain scores at 6 and 24 hours post-IVI compared to placebo (P=0.047).
  • The patching group showed a non-significant trend towards lower pain scores than the control group.

Conclusions:

  • Topical nepafenac 0.3% is effective in alleviating pain at 6 and 24 hours after IVI.
  • Patching demonstrated a trend but not statistically significant pain reduction.
  • Further research is needed to optimize post-IVI patient comfort without compromising outcomes.