Related Experiment Video
Updated: Jan 23, 2026
07:54
In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
Published on: September 20, 2012
14.2K
Expanding chemogenomic space using chemoproteomics.
1Jnana Therapeutics, 50 Northern Avenue, Boston 02210, USA.
Bioorganic & Medicinal Chemistry
|June 22, 2019
Summary
Chemogenomics and chemoproteomics accelerate drug target discovery. New chemical probes and mass spectrometry expand the range of druggable proteins, enabling the development of novel therapeutics.
Area of Science:
- Biochemistry
- Pharmacology
- Chemical Biology
Background:
- Chemogenomics aids in identifying drug targets from phenotypic screens.
- A significant portion of the proteome lacks selective modulators, highlighting the need for expanded chemogenomic tools.
Purpose of the Study:
- To describe the role of chemoproteomics in mapping small molecule-protein interactions.
- To explore opportunities for advancing chemoproteomics with medicinal chemical biology.
Main Methods:
- Utilizing functionalized chemical probes to identify protein interactions.
- Employing mass spectrometry for the analysis of small molecule-protein binding.
Main Results:
- Chemoproteomics effectively maps interactions between small molecules and proteins within cellular environments.
- This approach has facilitated the discovery of novel pharmacological modulators for various proteins.
Conclusions:
- Chemoproteomics is a powerful platform for exploring the ligandable proteome.
- Integrating medicinal chemical biology can further enhance the impact of chemoproteomics in drug discovery.
Related Concept Videos
01:27State Space Representation
541
The frequency-domain technique, commonly used in analyzing and designing feedback control systems, is effective for linear, time-invariant systems. However, it falls short when dealing with nonlinear, time-varying, and multiple-input multiple-output systems. The time-domain or state-space approach addresses these limitations by utilizing state variables to construct simultaneous, first-order differential equations, known as state equations, for an nth-order system.
Consider an RLC circuit, a...
Consider an RLC circuit, a...
541
01:25Space Trusses
1.3K
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. The space truss is widely used in various construction projects due to its adaptability and capacity to withstand complex loads.
At the core of a space truss lies the fundamental unit known as the tetrahedron. This structure is composed of six members that form a three-dimensional shape...
At the core of a space truss lies the fundamental unit known as the tetrahedron. This structure is composed of six members that form a three-dimensional shape...
1.3K
01:23Transfer Function to State Space
774
State-space representation is a powerful tool for simulating physical systems on digital computers, necessitating the conversion of the transfer function into state-space form. Consider an nth-order linear differential equation with constant coefficients, like those encountered in an RLC circuit. The state variables are selected as the output and its n−1 derivatives. Differentiating these variables and substituting them back into the original equation produces the state equations.
In an RLC...
In an RLC...
774
01:21State Space to Transfer Function
567
The conversion of state-space representation to a transfer function is a fundamental process in system analysis. It provides a method for transitioning from a time-domain description to a frequency-domain representation, which is crucial for simplifying the analysis and design of control systems.
The transformation process begins with the state-space representation, characterized by the state equation and the output equation. These equations are typically represented as:
The transformation process begins with the state-space representation, characterized by the state equation and the output equation. These equations are typically represented as:
567
01:29Space Trusses: Problem Solving
885
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. Due to its adaptability and capacity to withstand complex loads, the space truss is widely used in various construction projects.
Consider a tripod consisting of a tetrahedral space truss with a ball-and-socket joint at C. Suppose the height and lengths of the horizontal and vertical...
Consider a tripod consisting of a tetrahedral space truss with a ball-and-socket joint at C. Suppose the height and lengths of the horizontal and vertical...
885
01:13Rocket Propulsion in Empty Space - I
3.8K
The driving force for the motion of any vehicle is friction, but in the case of rocket propulsion in space, the friction force is not present. The motion of a rocket changes its velocity (and hence its momentum) by ejecting burned fuel gases, thus causing it to accelerate in the direction opposite to the velocity of the ejected fuel. In this situation, the mass and velocity of the rocket constantly change along with the total mass of ejected gases. Due to conservation of momentum, the...
3.8K