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Updated: Jan 23, 2026
Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Functional Aging Index Complements Frailty in Prediction of Entry Into Care and Mortality
Deborah Finkel1,2, Ola Sternäng2,3, Juulia Jylhävä4
1Department of Psychology, Indiana University Southeast, New Albany.
Background:
The aim of this study was to develop a functional aging index (FAI) that taps four body systems: sensory (vision and hearing), pulmonary, strength (grip strength), and movement (gait speed) and to test the predictive value of FAI for entry into care and mortality.
Method:
Growth curve models and Cox regression models were applied to data from 1,695 individuals from three Swedish longitudinal studies of aging. Participants were aged 45-93 at intake and data from up to eight follow-up waves were available.
Results:
The rate of change in FAI was twice as fast after age 75 as before, women demonstrated higher mean FAI, but no sex differences in rates of change with chronological age were identified. FAI predicted entry into care and mortality, even when chronological age and a frailty index were included in the models. Hazard ratios indicated that FAI was a more important predictor of entry into care for men than women, whereas it was a stronger predictor of mortality for men than women.
Conclusions:
Measures of biological aging and functional aging differ in their predictive value for entry into care and mortality for men and women, suggesting that both are necessary for a complete picture of the aging process across genders.
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