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Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Regulated Protein Degradation02:58

Regulated Protein Degradation

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
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Regulated Protein Degradation02:58

Regulated Protein Degradation

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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.0K
Protein Modifications in the RER01:26

Protein Modifications in the RER

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Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...
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Updated: Jan 23, 2026

Study of Protein-protein Interactions in Autophagy Research
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Protein methylation functions as the posttranslational modification switch to regulate autophagy.

Rui Li1, Xiang Wei1,2,3,4, Ding-Sheng Jiang5,6,7,8

  • 1Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan, 430030, China.

Cellular and Molecular Life Sciences : CMLS
|June 22, 2019
PubMed
Summary

Protein methylation, a key epigenetic process, is increasingly linked to autophagy regulation. Further research is needed to clarify its precise roles in autophagosome formation and signaling pathways.

Keywords:
AutophagyAutophagy-related proteinsDemethylaseHistone methylationMethyltransferaseNon-histone protein methylationPosttranslational modificationProtein methylation

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cellular Biology

Background:

  • Autophagy is crucial for cellular homeostasis and disease pathogenesis.
  • Cytoplasmic autophagy mechanisms are well-understood.
  • Posttranscriptional and epigenetic regulation of autophagy remain largely unexplored.

Purpose of the Study:

  • To summarize current knowledge on protein methylation's role in autophagy.
  • To highlight the impact of protein methylation on autophagy.
  • To discuss future research directions in this field.

Main Methods:

  • Literature review of recent studies on protein methylation and autophagy.
  • Analysis of the association between protein methylation and autophagy processes.
  • Synthesis of findings regarding epigenetic modifications in autophagy.

Main Results:

  • Protein methylation, encompassing histone and non-histone modifications, is a significant epigenetic regulator.
  • Emerging evidence links protein methylation to autophagosome formation, autophagy-related protein expression, and signaling pathway activation.
  • The precise molecular details of these associations require further investigation.

Conclusions:

  • Protein methylation represents a critical, yet understudied, layer of autophagy regulation.
  • Understanding protein methylation in autophagy is essential for elucidating its role in health and disease.
  • Future research should focus on elucidating the specific mechanisms by which protein methylation influences autophagy.