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Related Experiment Videos

Cocaine-calcium channel antagonist interactions.

M C Rowbotham1, W D Hooker, J Mendelson

  • 1Drug Dependence Research Center, Langley Porter Psychiatric Institute, University of California, San Francisco 94143.

Psychopharmacology
|January 1, 1987
PubMed
Summary

Diltiazem, a calcium channel blocker, did not significantly alter most cocaine effects in healthy men. However, it did reduce cocaine's impact on skin temperature, suggesting potential interactions.

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Area of Science:

  • Pharmacology
  • Cardiovascular Science
  • Neuroscience

Background:

  • Cocaine is a stimulant with significant cardiovascular and psychoactive effects.
  • Calcium channel antagonists are known to interact with cocaine's mechanisms in preclinical studies.
  • Understanding these interactions is crucial for managing cocaine toxicity and potential therapeutic interventions.

Purpose of the Study:

  • To investigate the effects of diltiazem, a calcium channel antagonist, on the physiological and subjective responses to cocaine in healthy human subjects.
  • To determine if diltiazem can mitigate the adverse effects of cocaine.

Main Methods:

  • A double-blind, placebo-controlled, two-session study involving six healthy men.
  • Participants received a single 60 mg oral dose of diltiazem or placebo 120 minutes before intravenous cocaine administration (0.2 mg/kg).

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  • Measurements included blood pressure, heart rate, pupil size, skin temperature, and subjective "high" ratings.

    • Main Results:

    • Cocaine administration significantly increased blood pressure, heart rate, pupil size, and subjective "high" ratings, while decreasing skin temperature.
    • Diltiazem alone had no significant effects.
    • Diltiazem pretreatment attenuated the decrease in skin temperature caused by cocaine but did not alter other cocaine-induced effects.

    Conclusions:

    • Diltiazem pretreatment partially mitigated cocaine's effect on skin temperature in humans.
    • The findings suggest that while calcium channel antagonists may have some interaction with cocaine's effects, the overall impact on key physiological and subjective responses was limited in this study.
    • Dosage and tissue-specific sensitivities may play a critical role in the interaction between calcium channel antagonists and cocaine.