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Fatigue in children with perinatal stroke: clinical and neurophysiological associations

James G Wrightson1, Ephrem Zewdie2,3,4,5, Hsing-Ching Kuo2,3,4,5

  • 1Human Performance Laboratory, University of Calgary, Calgary, AB, Canada.

Developmental Medicine and Child Neurology
|June 22, 2019
PubMed

Insights

Fatigue is common in children with hemiparesis after perinatal stroke, impacting motor skills in the less affected hand. Preserved ipsilateral corticospinal pathways are linked to reduced fatigue.

Area of Science:

  • Pediatric Neurology
  • Neurorehabilitation
  • Child Development

Background:

  • Perinatal stroke can lead to hemiparesis in children.
  • Fatigue is a frequently reported symptom in pediatric neurological conditions.
  • Understanding fatigue is crucial for optimizing rehabilitation outcomes.

Purpose of the Study:

  • To characterize fatigue in children with hemiparesis resulting from perinatal stroke.
  • To explore the relationship between fatigue and motor performance.
  • To investigate associations with corticospinal tract excitability.

Main Methods:

  • Forty-five children (6-18 years) with perinatal stroke participated.
  • Fatigue was assessed using the Pediatric Quality of Life Inventory cerebral palsy module.
  • Motor performance (Assisting Hand Assessment, Box and Blocks Test, grip strength) and corticospinal excitability were measured.

Main Results:

  • Nearly half of the participants reported fatigue.
  • Fatigue correlated with motor function and grip strength in the less affected hand.
  • Preserved ipsilateral corticospinal projections to the more affected hand were associated with less fatigue and correlated with projection excitability.

Conclusions:

  • Fatigue is prevalent in children with hemiparesis due to perinatal stroke.
  • Fatigue is linked to motor performance and corticospinal pathway characteristics.
  • Targeting corticospinal excitability may be a potential strategy for managing fatigue.
Abstract

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