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Updated: Jan 23, 2026

Design of Solid-State Fermentation Systems for Polymer Hydrolytic Extracellular Enzyme Production by Filamentous Fungi
Published on: June 6, 2025
[Regulatory mechanism underlying mycelium aggregation during filamentous fungi submerged fermentation]
Ruisang Liu1,2, Yajie Tang2, Fengwu Bai1,3
1School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, Liaoning, China.
Abstract:
Filamentous fungi are one of the platforms for producing fermented products. The specific characteristic of their submerged fermentation is the aggregation of mycelia that is affected by environmental conditions, leading to significantly different rheology for fermentation broth. Such a rheological change not only affects the transfer of mass, heat and momentum, but also the biosynthesis of target products and the efficiency of their production. In this article, strategies for morphological regulation of filamentous fungi are reviewed, and the impact of calcium signal transduction and chitin biosynthesis on apical growth of hyphae and branching of mycelia for their aggregation are further commented.
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