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Filaggrin and atopic march.

Ivana Čepelak1, Slavica Dodig1, Ivan Pavić2

  • 1Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.

Biochemia Medica
|June 22, 2019
PubMed
Summary

Filaggrin deficiency is linked to atopic dermatitis, a precursor to asthma and allergies. Understanding filaggrin

Keywords:
atopic dermatitisatopic diseasesfilaggrin

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Area of Science:

  • Dermatology and Immunology
  • Genetics and Molecular Biology

Background:

  • Atopic dermatitis (AD) is a chronic skin condition often preceding other atopic diseases.
  • AD involves immune system and skin barrier dysfunction.
  • Filaggrin is crucial for skin barrier integrity, regulating pH, hydration, and antimicrobial functions.

Purpose of the Study:

  • To review current research on filaggrin's role in atopic dermatitis.
  • To explore filaggrin's involvement in the 'atopic march' – the progression to other allergic conditions.
  • To summarize filaggrin's association with various cutaneous and non-cutaneous diseases.

Main Methods:

  • Literature review of experimental, genetic, and clinical studies.
  • Synthesis of recent findings on filaggrin's function and dysfunction.
  • Analysis of filaggrin's role in disease pathogenesis.

Main Results:

  • Filaggrin deficiency is associated with AD and other skin conditions like ichthyosis vulgaris.
  • Lack of filaggrin is also linked to non-cutaneous diseases, including gastrointestinal issues and diabetes.
  • Genetic, immune, and environmental factors contribute to filaggrin dysfunction.

Conclusions:

  • Filaggrin plays a significant role in maintaining skin barrier function.
  • Filaggrin deficiency is a key factor in atopic dermatitis pathogenesis and the development of other atopic diseases.
  • Further research into filaggrin is vital for understanding and managing atopic conditions.