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High-sensitivity cardiac Troponin T delta concentration after repeat pulmonary vein isolation

Ivan Zeljkovic1, Sven Knecht1,2, Florian Spies1,2

  • 1Cardiology Department, University Hospital Basel, University of Basel, Basel, Switzerland.

Biochemia Medica
|June 22, 2019
PubMed

Insights

High-sensitivity cardiac troponin T (hs-cTnT) changes after repeat pulmonary vein isolation (PVI) do not predict atrial fibrillation recurrence. Measuring hs-cTnT after repeat PVI offers no additional outcome information.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Biomarkers

Background:

  • Myocardial injury after ablation procedures can be assessed by changes in high-sensitivity cardiac troponin T concentrations (hs-cTnT).
  • Atrial fibrillation (AF) recurrence is a concern after pulmonary vein isolation (PVI).

Purpose of the Study:

  • To evaluate the prognostic value of hs-cTnT delta concentrations in predicting AF recurrence following repeat PVI.
  • To determine if hs-cTnT measurements provide additional clinical information after repeat PVI.

Main Methods:

  • A cohort of 105 patients with paroxysmal AF undergoing repeat PVI were studied.
  • Hs-cTnT levels were measured pre-procedure and 18-24 hours post-procedure.
  • Follow-up at 3, 6, and 12 months assessed AF recurrence, with Cox-regression analysis for predictors.

Main Results:

  • AF recurred in 23% of patients after a median 12-month follow-up.
  • A weak correlation was found between radiofrequency energy delivery time and hs-cTnT delta (R² = 0.31, P = 0.030).
  • Hs-cTnT delta was not a significant predictor of long-term AF recurrence after repeat PVI (P = 0.920).

Conclusions:

  • This study indicates that hs-cTnT delta does not predict AF recurrence after repeat PVI.
  • Routine hs-cTnT measurement post-repeat PVI does not enhance outcome prediction.
Abstract

Keywords:
atrial fibrillationhigh-sensitivity troponin Tpulmonary vein isolationrecurrencerepeat procedure

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