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A clinical experience with ADSOL preserved erythrocytes
C R Valeri1, L E Pivacek, M Palter
1Naval Blood Research Laboratory, Boston University School of Medicine, Massachusetts 02118.
Surgery, Gynecology & Obstetrics
|January 1, 1988
Summary
ADSOL preservative impacts erythrocyte viability. Human red blood cells stored in ADSOL showed acceptable 24-hour post-transfusion survival only after 35 days at 4°C.
Area of Science:
- Blood banking and transfusion medicine
- Erythrocyte preservation
- Biochemistry of blood storage
Background:
- Optimizing red blood cell (erythrocyte) storage is crucial for transfusion efficacy.
- ADSOL (adenine, glucose, mannitol, sodium chloride) is a common additive solution for erythrocyte preservation.
- Understanding the impact of storage duration on post-transfusion survival is vital.
Purpose of the Study:
- To evaluate the effect of ADSOL on the 24-hour post-transfusion survival of human erythrocytes.
- To determine the maximum acceptable storage duration for erythrocytes in ADSOL at 4°C.
Main Methods:
- Human erythrocytes were stored in ADSOL at 4°C for 35, 42, and 49 days.
- Post-transfusion survival was assessed at 24 hours for each storage duration.
Main Results:
- Erythrocytes stored for 35 days in ADSOL exhibited acceptable 24-hour post-transfusion survival.
- Storage durations of 42 and 49 days resulted in unacceptable post-transfusion survival rates.
Conclusions:
- ADSOL supports erythrocyte viability for up to 35 days of storage at 4°C.
- Extended storage beyond 35 days significantly compromises the 24-hour post-transfusion survival of human erythrocytes.
