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Related Experiment Videos

Calorie-nitrogen interactions in the parenterally fed primate.

D T Dempsey1, J L Mullen, L O Crosby

  • 1Philadelphia Veterans Administration Medical Center, Pa.

Surgery
|January 1, 1988
PubMed
Summary

Nitrogen intake, not nonprotein calories, significantly impacts nitrogen balance and serum protein response in depleted primates receiving total parenteral nutrition (TPN). Nitrogen levels are key for nutritional repletion.

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Area of Science:

  • Nutritional Science
  • Primate Metabolism
  • Parenteral Nutrition

Background:

  • Nutritional depletion can impair nitrogen balance, weight gain, and serum protein levels.
  • Total parenteral nutrition (TPN) is a critical intervention for refeeding depleted patients.
  • The relative importance of nonprotein calories versus nitrogen in TPN for depleted subjects requires clarification.

Purpose of the Study:

  • To determine if nonprotein calorie intake and nitrogen intake are equally crucial for positive nitrogen balance, weight gain, and serum protein response in depleted primates receiving TPN.
  • To investigate the impact of varying nonprotein caloric and nitrogen levels within TPN on key physiological markers.

Main Methods:

  • Ten adult male Macaca fascicularis primates underwent a 10-day nutritional depletion phase.

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  • Animals were subsequently randomized to receive one of four TPN diets with varying nonprotein caloric (100% or 155% of resting energy expenditure) and nitrogen (100% or 200% of requirement) levels.
  • A depletion-repletion cycle was repeated to ensure all animals received all four diets.

    • Main Results:

    • Higher nitrogen intake significantly improved nitrogen balance (p = 0.01) and serum total iron-binding capacity response (p = 0.02).
    • Nonprotein calorie intake significantly influenced weight gain (p = 0.03) but not nitrogen balance or serum protein response.
    • Fluid balance did not differ significantly across the dietary groups.

    Conclusions:

    • Nitrogen intake level is a more critical determinant than nonprotein calorie intake for achieving positive nitrogen balance and improving serum protein status in TPN-treated depleted primates.
    • Weight gain is primarily influenced by nonprotein calorie availability.
    • Selective repletion of fat and protein stores is achievable by modulating the nonprotein calorie and nitrogen content of TPN regimens.