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Published on: February 16, 2011
Analysis of microbiota in elderly patients with Acute Cerebral Infarction
Lin Huang1, Teng Wang1, Qian Wu1
1Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background And Aims:
Recent evidence suggest that microbiota is associated with almost all major types of diseases, including cardiovascular diseases. However, its role in Acute Cerebral Infarction remains unexplored. It is important to understand the diversity and distribution of gut microbiota (GM) in patients with Acute Cerebral Infarction and the role that GM plays in this type of disease.
Methods:
We performed pyrosequencing on the gut microbiota of 40 individuals in order to elucidate whether the composition of the microbiota differs between patients with Acute Cerebral Infarction and healthy controls: Of these individuals, there were 31 with Acute Cerebral Infarction and nine controls. We applied linear regression to calculate the correlation between the gut flora and disease risk factors. Finally, KEGG functional enrichment analysis was conducted to examine the correlation between the gut flora and Acute Cerebral Infarction.
Results:
The overall microbial structure was similar in both the controls and the patients, but the control group had higher relative presence of Blautia obeum while the presence of Streptococcus infantis and Prevotella copri were relatively higher in the patient group. Using linear regression, we found that Blautia obeum was negatively associated with white blood cell count and Streptococcus infantis was positively correlated with creatinine and lipoprotein. The KEGG pathway analysis indicated that the bio-pathways including methane metabolism, lipopolysaccharide synthesis, bacterial secretion, and flagellar assembly of the gut microbiota in the patient group was expressed differently than that of the controls. We identified three differentially expressed gut microbial functions in Acute Cerebral Infarction and found four bacterial pathways that might be related to the development of this disease.
Conclusions:
Our study identified three abnormally-expressed bacteria-Blautia obeum, Streptococcus infantis, and Prevotella copri-in patients with Acute Cerebral Infarction compared with healthy controls. It reveals a correlation of these bacterial species with Acute Cerebral Infarction as they relate to disease factors and functional pathways. These findings may shed light on the treatment of cerebral infarction because gut microbiota could serve as a potential therapeutic approach for the treatment of cardiovascular and metabolic diseases.
Insights
Gut microbiota composition differs in acute cerebral infarction patients. Specific bacteria like Blautia obeum, Streptococcus infantis, and Prevotella copri were abnormally expressed, potentially offering new therapeutic targets.
Area of Science:
- Microbiome research
- Neuroscience
- Cardiovascular disease research
Background:
- Emerging evidence links gut microbiota to various diseases, including cardiovascular conditions.
- The specific role of gut microbiota in Acute Cerebral Infarction (ACI) remains largely uninvestigated.
- Understanding gut microbiota diversity in ACI patients is crucial for disease insight.
Purpose of the Study:
- To investigate the diversity and distribution of gut microbiota in ACI patients.
- To identify differences in gut microbiota composition between ACI patients and healthy controls.
- To explore the correlation between gut microbiota and ACI risk factors and pathways.
Main Methods:
- Pyrosequencing of gut microbiota from 40 individuals (31 ACI patients, 9 controls).
- Linear regression analysis to correlate gut flora with disease risk factors.
- KEGG functional enrichment analysis to examine gut flora-ACI correlations.
Main Results:
- While overall microbial structure was similar, controls had more Blautia obeum, whereas ACI patients had higher Streptococcus infantis and Prevotella copri.
- Blautia obeum negatively correlated with white blood cell count; Streptococcus infantis correlated with creatinine and lipoprotein.
- KEGG analysis revealed differential expression in methane metabolism, lipopolysaccharide synthesis, and other pathways in ACI patients.
Conclusions:
- Three bacteria (Blautia obeum, Streptococcus infantis, Prevotella copri) showed abnormal expression in ACI patients.
- These bacteria correlate with ACI, disease factors, and functional pathways.
- Gut microbiota represents a potential therapeutic avenue for cerebral infarction and related diseases.
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