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Association of rs2910164 Polymorphism in miRNA-146 and rs3746444 Polymorphism in miRNA-499 with Inflammatory

Dingjian Wang1, Guixia Pan1

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.

Biomed Research International
|June 22, 2019
PubMed
Abstract

Insights

MicroRNA-499 (miRNA-499) rs3746444 polymorphism is linked to inflammatory arthritis. MicroRNA-146 (miRNA-146) rs2910164 polymorphism shows no association with inflammatory arthritis susceptibility.

Area of Science:

  • Genetics and Molecular Biology
  • Immunology
  • Rheumatology

Background:

  • MicroRNAs (miRNAs) play crucial roles in regulating gene expression.
  • Aberrant miRNA expression is implicated in the pathogenesis of various diseases, including inflammatory arthritis.
  • Specific miRNA polymorphisms may influence susceptibility to inflammatory arthritis.

Purpose of the Study:

  • To investigate the association between specific polymorphisms in miRNA-146 (rs2910164) and miRNA-499 (rs3746444) and the risk of developing inflammatory arthritis.
  • To conduct a meta-analysis of existing studies to consolidate evidence on these associations.

Main Methods:

  • A systematic literature search was performed across major scientific databases (PubMed, Web of Science, Elsevier ScienceDirect, Cochrane Library).
  • 18 case-control studies involving 3385 patients with inflammatory arthritis and 4584 controls were included in the meta-analysis.
  • Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association.

Main Results:

  • The meta-analysis revealed a significant association between the miRNA-499 rs3746444 polymorphism (C vs T) and increased inflammatory arthritis susceptibility (OR: 1.422, P=0.001).
  • This association for miRNA-499 rs3746444 was consistent across regional subgroup analyses.
  • No significant association was found between the miRNA-146 rs2910164 polymorphism (C vs T) and inflammatory arthritis susceptibility in the overall population (OR: 1.061, P=0.365).

Conclusions:

  • The miRNA-499 rs3746444 polymorphism is associated with an increased risk of inflammatory arthritis.
  • The miRNA-146 rs2910164 polymorphism does not appear to be associated with inflammatory arthritis susceptibility.
  • Further large-scale studies are recommended to validate these findings, particularly in specific populations like the Middle East.

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