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Multiple Influenza Virus Infections in 4 Consecutive Epidemiological Seasons: A Retrospective Study in Children and

Johannes Möst1, Monika Redlberger-Fritz2, Günter Weiss3

  • 1MB-LAB-Clinical Microbiology Laboratory, Innsbruck, Austria.

Open Forum Infectious Diseases
|June 22, 2019
PubMed
Abstract

Insights

Children and adolescents frequently experience repeat influenza infections, with over 18% having multiple flu episodes in a single season. Understanding this pattern is key for improving influenza vaccination strategies.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Immunology

Background:

  • Emerging evidence suggests group-specific immunity to influenza A.
  • This raises questions about the frequency of recurrent influenza infections.

Purpose of the Study:

  • To investigate the occurrence and patterns of repetitive influenza infections in children and adolescents.
  • To analyze the frequency of influenza reinfections over multiple epidemiological seasons.

Main Methods:

  • Retrospective analysis of 2308 children and adolescents with confirmed influenza.
  • Data collected over four epidemiological seasons (2014-15 to 2017-18).
  • Included clinically manifested influenza cases with positive PCR tests.

Main Results:

  • 12% of patients in 2015-16 had a prior season's infection; over 18% in 2017-18 had infections in previous seasons.
  • Repetitive infections were most common in children aged 3-8 years.
  • 29 patients had 3-4 infections, and 38 had 2 infections in the same season.

Conclusions:

  • Repetitive influenza infections are frequent in pediatric populations.
  • Findings enhance understanding of influenza virus immunity.
  • Results may inform future influenza vaccination strategies.
Keywords:
childrenepidemiologyinfluenzamultiple infections

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