Related Experiment Video
Updated: Aug 8, 2026

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
Cellular parameters of the immunological memory induced by lysozyme-LPS mixtures and complexes
Abstract:
The primary antibody response to the protein antigen lysozyme can be enhanced many fold by complexing the antigen with lipopolysaccharide (LPS). This complex, as well as lysozyme/LPS admixtures, is also capable of inducing a state of lysozyme specific immunological memory. Investigation of this memory state has revealed that administration of lysozyme either admixed or complexed with LPS results in priming of both B and T lymphocytes. Adoptive transfer of secondary responsiveness from animals primed in either fashion was further found to be T cell dependent. The implications of these findings are discussed.
Related Concept Videos
Cells of the Adaptive Immune Response
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...

