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Updated: Jan 23, 2026

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Central venous catheter use increases ischemic stroke risk: a nationwide population-based study

P-H Liao1, C-Y Lai2,3, C-H Wu1

  • 1Department of Emergency Medicine, Tungs Taichung Metro Harbor Hospital, Taichung, Taiwan.

QJM : Monthly Journal of the Association of Physicians
|June 22, 2019
PubMed

Insights

Central venous catheter (CVC) placement increases ischemic stroke risk, especially in patients under 35. This study highlights the need for further investigation into this association.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Medical Procedures

Background:

  • Central venous catheter (CVC) placement is a frequent procedure for critically ill patients.
  • Ischemic stroke is a known complication associated with CVC placement.

Purpose of the Study:

  • To investigate the association between CVC placement and ischemic stroke risk.
  • Focus on an Asian population to understand specific risk factors.

Main Methods:

  • Population-based retrospective study utilizing the Taiwan National Health Insurance Research Database.
  • Propensity score matching was employed to compare 34,164 patients with CVC placement against a control group without CVC placement.
  • Analysis included cumulative incidence rates and adjusted hazard ratios (aHRs) for ischemic stroke.

Main Results:

  • CVC placement was associated with a significantly increased annual incidence of ischemic stroke (19.5 vs. 11.6 per 10,000 person-years; aSHR=1.4).
  • Patients aged 35 years or younger with CVC placement exhibited a markedly higher stroke risk (aSHR=14.3) compared to older patients.
  • Within one year of follow-up, the ischemic stroke incidence rate was approximately 3.25-fold higher in the CVC group.

Conclusions:

  • Central venous catheter placement elevates the risk of ischemic stroke.
  • The increased risk is particularly pronounced in younger patients (≤35 years).
  • Further research is warranted to explore the mechanisms and implications of this finding.
Abstract

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