Awake Craniotomy and Resection of a Left Frontal High-Grade Glioma: 2-Dimensional Operative Video

A 48-yr-old female patient presented in our outpatients' clinic after an episode of speech arrest and seizures a week earlier. On physical examination, there were no neurological deficits. Cranial magnetic resonance imaging (MRI) revealed a contrast-enhancing tumor of the superior and middle frontal gyrus. A 18F-fluoroethyl-tyrosine positron emission tomography (FET-PET) showed a high tracer uptake, and we suspected the lesion to be a high-grade glioma. The tumor was located next to the cortical motor and language areas. We performed a left frontal craniotomy while the patient was asleep, and then conducted cortical and subcortical stimulation under an awake condition. The patient was asked to move her right upper extremity and to name objects. Based on MRI navigation, we achieved a complete tumor resection. Postoperative imaging confirmed gross total resection, and final histopathology revealed an anaplastic astrocytoma isocitrate dehydrogenase (IDH) mut, 1p19q noncodeleted WHO°III. The patient was discharged home on the fifth postoperative day with a supplementary motor area syndrome and diminishing word-finding difficulties. We safely achieved gross total tumor resection in a highly eloquent localization through awake craniotomy with direct cortical and subcortical stimulation and electrophysiological monitoring. Awake craniotomy remains the gold standard for tumor resection in eloquent language areas in our clinics.  We obtained informed consent from the patient.