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Encainide-induced hyperglycemia.

D M Salerno¹, J Fifield, J Krejci

¹Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis 55415.

The American Journal of Medicine

|January 1, 1988

Summary

This summary is machine-generated.

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Encainide, an antiarrhythmic drug, can worsen hyperglycemia in some patients. Blood glucose levels significantly increased during treatment, requiring insulin, but decreased after stopping encainide.

Area of Science:

Cardiology
Endocrinology
Pharmacology

Background:

Encainide is a novel antiarrhythmic medication.
The impact of encainide on glucose metabolism was previously unstudied.

Observation:

Twenty-three patients received encainide for at least one month.
Four patients developed marked hyperglycemia (serum glucose ≥ 200 mg/dL) during encainide therapy.

Findings:

Hyperglycemic patients showed a significant increase in mean glucose levels from 190 mg/dL to 397 mg/dL after one month of encainide (p < 0.025).
Non-hyperglycemic patients maintained stable glucose levels (111 mg/dL pre-treatment, 108 mg/dL post-treatment).
Encainide dosage and patient age did not differ between groups.

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Implications:

Encainide can exacerbate hyperglycemia, potentially necessitating insulin therapy.
Discontinuation of encainide led to decreased hyperglycemia and reduced insulin requirements.
The mechanism underlying encainide's effect on glucose metabolism and long-term consequences remain unknown.