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Updated: Jan 23, 2026
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
12.9K
Systemic Immunologic Consequences of Chronic Periodontitis.
D K Gaudilliere1, A Culos2, K Djebali2
11 Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University, Stanford, CA, USA.
Journal of Dental Research
|June 22, 2019
Summary
Chronic periodontitis (ChP) causes widespread immune system dysfunction, marked by exaggerated inflammatory responses and weakened natural killer cell activity. These systemic immune alterations are reversible with periodontal treatment.
Area of Science:
- Immunology
- Periodontology
- Oral Health
Background:
- Chronic periodontitis (ChP) is a common inflammatory disease linked to systemic conditions like cardiovascular disease.
- The mechanisms connecting ChP to adverse systemic health outcomes remain unclear.
- ChP affects 46% of the US population, leading to alveolar bone destruction and tooth loss.
Purpose of the Study:
- To investigate the systemic immune consequences of ChP.
- To analyze immune system-wide dysfunctions in ChP patients.
- To determine if periodontal treatment reverses these immune alterations.
Main Methods:
- Prospective cohort study design.
- Utilized highly multiplex mass cytometry immunoassay for in-depth analysis.
- Analyzed intracellular signaling networks in circulating immune cells.
Main Results:
- Identified immune system-wide dysfunctions distinguishing ChP patients from healthy controls.
- Observed exaggerated proinflammatory responses in neutrophils and monocytes to Porphyromonas gingivalis LPS.
- Noted attenuated natural killer cell responses to inflammatory cytokines in ChP patients.
- Found immune alterations were undetectable 3 weeks after periodontal treatment.
Conclusions:
- Demarcated systemic and cell-specific immune dysfunctions in ChP patients.
- Demonstrated temporary reversal of immune alterations following local ChP treatment.
- Highlighted the need for further research in larger cohorts to confirm generalizability.
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