Multimodal Integrated Sensor Platform for Rapid Biomarker Detection.

Area of Science:

• Microelectronics Engineering
• Biomedical Sensing
• Personalized Medicine

Background:

• Current disease diagnosis relies on multiple tests and large equipment, hindering personalized medicine and point-of-care applications.
• Advancements in microelectronics and integrated circuits are crucial for developing compact, efficient sensor platforms.
• The need for cost-effective, rapid diagnostic tools is paramount for widespread adoption in healthcare.

Purpose of the Study:

• To develop a versatile, single complementary metal-oxide-semiconductor (CMOS) chip for on-chip multimodal detection.
• To create a platform reducing the number of tests required for personalized diagnostics.
• To enable cost-effective, rapid disease diagnosis at the point-of-care.

Main Methods:

• Integration of interleaved sensing subsystems for colorimetric, chemiluminescent, surface plasmon resonance (SPR), and hydrogen ion measurements on a single chip.
• Inclusion of photodiode and single photon avalanche diode arrays, with SPR-functionalized elements.
• Utilization of ion-sensitive field-effect transistors (ISFETs) and bio-functionalization for selective, simultaneous assays.

Main Results:

• Demonstration of a scalable, modular sensor array design on a disposable chip.
• Successful quantification of glucose, cholesterol, urea, and urate within physiological ranges using on-chip bio-assays.
• Achieved simultaneous multiple-assay capability with high selectivity.

Conclusions:

• The developed single-chip platform offers a versatile solution for personalized medicine and point-of-care diagnostics.
• On-chip multimodal detection significantly reduces testing complexity and cost.
• This technology holds promise for advancing rapid and accurate disease diagnosis.