Related Experiment Video
Updated: Jan 23, 2026
09:11
Visualizing Dengue Virus through Alexa Fluor Labeling
Published on: July 9, 2011
14.4K
Assessing dengue control in Tokyo, 2014.
Baoyin Yuan1,2, Hyojung Lee1,2, Hiroshi Nishiura1,2
1Graduate School of Medicine, Hokkaido University, Sapporo-shi, Hokkaido, Japan.
Plos Neglected Tropical Diseases
|June 22, 2019
Summary
Closing Yoyogi Park in Tokyo successfully halted dengue transmission. Mathematical modeling showed park closure, alongside mosquito control and risk communication, reduced the effective reproduction number, demonstrating effective dengue outbreak control.
Area of Science:
- Epidemiology
- Mathematical Modeling
- Public Health
Background:
- An autochthonous dengue outbreak occurred in Tokyo in summer 2014, with Yoyogi Park as the primary transmission hub.
- Control measures implemented included mosquito control, public announcements, and park closure.
Purpose of the Study:
- To assess the effectiveness of implemented dengue control measures during the 2014 Tokyo outbreak.
- To analyze the impact of interventions on dengue transmission dynamics using mathematical modeling.
Main Methods:
- A mathematical model was employed to simulate dengue transmission dynamics.
- Case data, including exposure and illness onset dates, were used to categorize infections.
- The effective reproduction number was estimated to evaluate intervention impact.
Main Results:
- Mosquito control and risk communication initiated on August 28, 2014, were insufficient to reduce the effective reproduction number below 1.
- Closure of Yoyogi Park on September 4, 2014, led to a decrease in the effective reproduction number below 1.
- The estimated relative reduction in the effective reproduction number ranged from 20% to 60% after park closure. The mean incubation period was estimated at 5.8 days.
Conclusions:
- The combined interventions, particularly the closure of Yoyogi Park, were successful in interrupting dengue transmission in Tokyo.
- Mathematical modeling provides valuable insights into the efficacy of public health interventions during infectious disease outbreaks.
Related Concept Videos
01:21Control System Problem
421
In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
421
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
416
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
416
02:33Combinatorial Gene Control
9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
01:10Control Systems
1.8K
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
At the heart...
1.8K
01:22Controller Configurations
360
Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation.
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
360
01:19PID Controller
685
Proportional-Integral-Derivative (PID) controllers are widely used in various control systems to enhance stability and performance. In a thermostat, it adjusts heating or cooling based on the temperature difference between the actual and desired levels. They are often used in automotive speed systems, effectively managing sudden speed changes while maintaining a constant speed under varying conditions. On the other hand, PI controllers, commonly employed in voltage regulation, enhance stability...
685